June 21, 2021 – UPMC Children’s Hospital of Pittsburgh is participating in the Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (PRoMPT BOLUS) to figure out what the best IV fluid options are for pediatric patients.
The purpose of this multi-center research study, involving over 20 children’s hospitals, is to determine if one type of IV fluid is better than another at protecting kidney function in treatment of pediatric patients with sepsis, a severe inflammatory response to an infection that can impair the normal function of certain organ systems.
Doctors will enroll patients who present to the emergency department with suspected septic shock and treat them with one of the commonly used fluids, unless patients opt out or decide to withdraw from study completion.
All IV solutions used in this study are approved by the U.S. Food and Drug Administration (FDA) and are recommended as part of standard care for sepsis, restoring fluid balance to improve blood pressure and lower heart rate.